Correlation of Age, Administration Method, and Amlodipine Dosage with the Risk of Side Effects in Hypertensive Patients

Q: What is the clinical evidence from this study?

Study design: Cross-Sectional. Population: Hypertension (n=84). Intervention: Age and Amlodipine dosage. Primary outcome: Risk of side effects (p=0.013 for age, 0.002 for dosage).

Q: What does this research mean for the field?

Patient age and amlodipine dosage are significantly correlated with the risk of experiencing adverse side effects, most commonly edema and dizziness, in individuals treated for hypertension. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

Tiara Rambu Renesia Tarapanjang; Magdarita Riwu; Christina Olly Lada; Derri Riskiyanti Tallo Manafe

doi:10.35508/cmj.v12i2.15537

July 16, 2025Cendana Medical JournalOpen Access

Correlation of Age, Administration Method, and Amlodipine Dosage with the Risk of Side Effects in Hypertensive Patients

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Key result

Higher amlodipine dosage is linked to a ~24-fold higher risk of edema in observational analysis.

P=0.013 for age, 0.002 for dosage
n=84

Why the study?

The correlation between age, Amlodipine dosage, and side effect risks in hypertensive patients required investigation to improve medication management.

Does age and amlodipine dosage correlate with the risk of side effects in hypertensive patients?

Key Points

To analyze the correlation between age, administration method, and amlodipine dosage with the risk of adverse side effects in hypertensive patients.
Conducted an observational analytic cross-sectional study involving 84 hypertensive outpatients aged 15–70 years between May and October 2023 at RSUD Prof. Dr. W. Z. Johannes Kupang.
Excluded patients on combination hypertension therapy, those taking other drugs sharing similar adverse effect profiles, or presenting baseline symptoms mimicking amlodipine side effects.
Analyzed clinical data from patient interviews and medical records using the chi-square test.
The most common adverse side effects reported were edema (38.10%), dizziness (28.57%), fatigue (17.85%), and nausea (15.48%).
Adverse side effect risks significantly correlated with patient age (p=0.013) and amlodipine dosage (p=0.002).

Study Design

Type

Cross-Sectional (n=84)

Multicenter

No

Structured PICO

Does age and amlodipine dosage correlate with the risk of side effects in hypertensive patients?

P

Population

84 outpatients aged 15-70 years with uncomplicated hypertension taking amlodipine were evaluated cross-sectionally for factors associated with adverse effects.

E

Exposure

Amlodipine 5 mg or 10 mg taken orally after meals.

O

Outcome

Risk of side effects (edema, dizziness, fatigue, nausea) correlated with age, administration method, and dosage.safety

Main Result

p-value: p=0.013 for age, 0.002 for dosage

Older age and higher amlodipine dosage (10 mg) are significantly associated with an increased risk of side effects, particularly edema, in hypertensive patients.

Limitations

Cross-sectional design cannot establish causality.
Did not account for other factors like diet and lifestyle due to the use of secondary data.
Inability to control external factors affecting the incidence of side effects.
Cross-sectional design cannot establish causality
Did not consider other factors like diet and lifestyle
Inability to control external factors affecting side effects

Implication

May support cautious amlodipine dosing in older patients; leaves open confirmation in prospective studies.

Abstract

Hypertension, known as the "silent killer," poses a global threat with potentially fatal consequences. Lifelong treatment, often involving Amlodipine, requires careful management of age, dosage, and administration to mitigate side effects and enhance patients' quality of life. This study at RSUD Prof. Dr. W. Z. Johannes Kupang aimed to explore the correlation between age, Amlodipine dosage, and side effect risks. Utilizing an observational analytic method with a cross-sectional approach, data from 84 patients, aged 15-70, were collected between May and October 2023. Predominant side effects included edema (38.10%), dizziness (28.57%), fatigue (17.85%), and nausea (15.48%). Findings indicated age (p=0.013) and Amlodipine dosage (p=0.002) correlated with side effect risks. However, administration method analysis was hindered by consistent post-meal consumption in all participants. In conclusion, this research underscores the relevance of age and Amlodipine dosage in side effect risks for hypertensive patients. Practical implications include refined medication management strategies to improve overall patient well-being.

Discussion

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Cite This Study

Tarapanjang et al. (2025) conducted a cross-sectional in Hypertension (n=84). Age and Amlodipine dosage was evaluated on Risk of side effects (p=0.013 for age, 0.002 for dosage). Older age and higher amlodipine dosage were significantly associated with an increased risk of side effects, with dosage strongly predicting edema (OR 24.17).

synapsesocial.com/papers/6ac2fd227180a622ddd4dfe3 https://doi.org/10.35508/cmj.v12i2.15537

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Correlation of Age, Administration Method, and Amlodipine Dosage with the Risk of Side Effects in Hypertensive Patients

Key Points

Study Design

Structured PICO

Main Result

Limitations

Implication

Abstract

Discussion

Cite This Study

Correlation of Age, Administration Method, and Amlodipine Dosage with the Risk of Side Effects in Hypertensive Patients

Key Points

Study Design

Structured PICO

Main Result

Limitations

Implication

Abstract

Discussion

Cite This Study

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