Why the study?
Does the pharmacodynamics and disposition of amlodipine differ between elderly and young patients with hypertension?
Population
Elderly (mean age 68 +/- 3 years) and young (mean age 35 +/- 5 years) patients with essential hypertension.
Comparison
Single intravenous amlodipine dose followed by… vs Young patients with hypertension receiving the…
Design
Cohort
Follow-up
12 weeks
Authors
Loading...
May warrant dosing caution in elderly; leaves open impact on efficacy and safety in hypertension.
Does the pharmacodynamics and disposition of amlodipine differ between elderly and young patients with hypertension?
Amlodipine is an effective once-daily antihypertensive in both elderly and young patients, though elderly patients exhibit prolonged elimination half-life and decreased clearance.
Gutkowska et al. (1990) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: