Why the study?
Does advanced age alter the pharmacokinetics of a single oral dose of amlodipine?
Population
16 elderly subjects and a group of young subjects.
Comparison
Amlodipine 5 mg single oral dose. vs Young subjects receiving the same single oral…
Design
Cohort
Authors
Loading...
May warrant dose adjustment in elderly patients; leaves open need for randomized outcome confirmation.
Does advanced age alter the pharmacokinetics of a single oral dose of amlodipine?
Elderly patients exhibit reduced clearance of amlodipine, resulting in a prolonged half-life and increased systemic exposure compared to younger individuals.
Elliott et al. (1988) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: