Key result
Older hypertensive patients showed approximately 30% higher AUC and plasma concentrations of felodipine and amlodipine compared to younger patients, with age markedly affecting BP response.
Why the study?
Does age impact the pharmacokinetics and blood pressure responses of felodipine-ER and amlodipine in patients with hypertension?
Population
63 patients with hypertension, divided into younger (n = 28) and older (n = 35) groups.
Comparison
Felodipine-ER 5 mg/d or amlodipine 5 mg/d vs Placebo
Design
RCT, randomized
Authors
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May warrant cautious dosing and monitoring in older hypertensives; confirms age effects on exposure and BP response.
RCT (n=63)
Does age impact the pharmacokinetics and blood pressure responses of felodipine-ER and amlodipine in patients with hypertension?
Age modestly impacts the pharmacokinetics of amlodipine and felodipine-ER but significantly affects the initial blood pressure response and the duration of action of chronic amlodipine dosing.
Leenen et al. (2010) conducted an RCT in Hypertension (n=63). Felodipine-ER or amlodipine vs. Placebo was evaluated on Pharmacokinetics and blood pressure (BP) responses. Older hypertensive patients showed approximately 30% higher AUC and plasma concentrations of felodipine and amlodipine compared to younger patients, with age markedly affecting BP response.
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