Why the study?
What are the population dose-response and concentration-response relationships of felodipine in patients with mild to moderate essential hypertension?
Population
239 evaluable patients with mild to moderate essential hypertension
Comparison
Extended-release felodipine monotherapy once daily vs Placebo
Design
RCT, randomized, double-blind
Follow-up
1 year
Authors
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Supports lower felodipine starting doses in elderly hypertensives; extends age-specific Emax modeling for antihypertensive dose-response.
What are the population dose-response and concentration-response relationships of felodipine in patients with mild to moderate essential hypertension?
Felodipine pharmacokinetics and pharmacodynamics are affected by age, leading to a heightened antihypertensive response in the elderly, suggesting a lower starting dose of 2.5 mg daily.
Wade et al. (1995) studied this question.
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