Why the study?
How do age, body mass index, and hypertension status affect the pharmacokinetics of felodipine?
Population
140 male and female Caucasian subjects, comprising 67 hypertensive patients and 73 healthy volunteers
Design
Cohort
Authors
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May warrant dosing caution in older adults; extends PK data but leaves open prospective titration trials.
How do age, body mass index, and hypertension status affect the pharmacokinetics of felodipine?
Age significantly alters the pharmacokinetics of felodipine, resulting in higher total concentrations in the elderly and emphasizing the need for individualized dose titration.
Blychert et al. (1991) studied this question.
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