Why the study?
What is the relationship between felodipine plasma concentration and antihypertensive effect in hypertensive patients and healthy subjects?
Population
67 patients with hypertension and 21 healthy subjects (n=88)
Design
Meta-analysis
Authors
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Supports Emax-based dosing predictions for felodipine in hypertension; confirms consistent concentration-effect relationship across studies.
What is the relationship between felodipine plasma concentration and antihypertensive effect in hypertensive patients and healthy subjects?
Felodipine exhibits a predictable concentration-effect relationship for blood pressure reduction in hypertensive patients, which is well-described by the Emax model.
Blychert et al. (1992) studied this question.
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