Why the study?
Does impaired renal function alter the pharmacokinetics and antihypertensive effects of felodipine in patients?
Population
18 patients treated with metoprolol for a month, including 12 with impaired renal function and 6 with normal…
Comparison
Felodipine 10 mg oral and 0.04 mg 3H-felodipine… vs Patients with normal renal function compared to…
Design
Cohort
Follow-up
29 days
Authors
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Supports no felodipine dose adjustment in renal impairment; leaves open confirmation in prospective trials.
Does impaired renal function alter the pharmacokinetics and antihypertensive effects of felodipine in patients?
Renal impairment does not alter the pharmacokinetics or pharmacodynamics of felodipine, indicating that no dosage adjustment is necessary for hypertensive patients with renal disease.
Larsson et al. (1990) studied this question.