Why the study?
Does acute and long-term treatment with felodipine alter renal haemodynamics and tubular function in patients with essential hypertension?
Population
10 patients with essential hypertension
Comparison
Acute and long-term treatment with felodipine vs Baseline (pre-treatment)
Design
Cohort
Authors
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Observational data link felodipine to sustained BP reduction with stable renal blood flow; leaves open confirmation in randomized trials.
Does acute and long-term treatment with felodipine alter renal haemodynamics and tubular function in patients with essential hypertension?
Felodipine effectively lowers blood pressure in essential hypertension while acutely increasing renal blood flow and promoting tubular excretion of electrolytes and urate.
Hulthén et al. (1988) studied this question.
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