What question did this study set out to answer?

May 1, 1985Journal of Cardiovascular Pharmacology

Systemic and Renal Hemodynamic Effects of Single Oral Doses of Felodipine in Patients with Refractory Hypertension Receiving Chronic Therapy with β-Blockers and Diuretics

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Why the study?

Does a single oral dose of felodipine improve central and renal hemodynamics in patients with refractory hypertension?

Population

12 patients with primary hypertension inadequately controlled by chronic standard triple therapy

Comparison

Single oral dose of felodipine solution… vs Baseline measurements (before-and-after design)

Design

Cohort

Follow-up

30 minutes

Authors

OAOve K. AnderssonUniversity of North Carolina at Chapel Hill GGGöran GranérusLinköping University THThomas HednerGeneral / Preventive / Lipids

Discussion

Member takes

Implication

Acute felodipine effects in refractory hypertension should not yet change practice; leaves open durability and outcomes in randomized trials.

Key Points

To assess the acute systemic and renal hemodynamic effects of single oral doses of felodipine in patients with refractory primary hypertension.
Administered a single oral dose of felodipine (0.075–0.1 mg/kg) in 12 patients with primary hypertension (WHO stage 2) uncontrolled by chronic therapy with beta-blockers and diuretics, substituting hydralazine.
Assessed central hemodynamics via dye dilution and determined renal plasma flow and glomerular filtration rate using para-aminohippuric acid and [51Cr]EDTA clearances.
Mean arterial pressure reached a maximal reduction of 23% at 30 minutes post-dose, demonstrating a linear relationship with log plasma felodipine concentration.
Cardiac output increased from 5.3 ± 1.0 to 6.6 ± 2.4 L/min (p < 0.01), driven by rises in heart rate from 57 ± 4 to 65 ± 9.1 beats/min (p < 0.01) and stroke volume from 93 ± 14 to 104 ± 33 ml (p < 0.05).
Renal plasma flow increased from 343 ± 138 to 391 ± 154 ml/min (p < 0.05) with unchanged glomerular filtration rate, while flow-corrected arteriovenous noradrenaline difference rose 36%.

Structured PICO

Does a single oral dose of felodipine improve central and renal hemodynamics in patients with refractory hypertension?

Population

12 patients with primary hypertension (World Health Organization stage 2) inadequately controlled by chronic standard triple therapy

Intervention

Single oral dose of felodipine solution (0.075-0.1 mg/kg) replacing hydralazine

Comparator

Baseline measurements (before-and-after design)

Outcome

Acute effects on central and renal hemodynamics (mean arterial pressure, cardiac output, heart rate, stroke volume, renal plasma flow, glomerular filtration rate)surrogate

A single oral dose of felodipine effectively reduces blood pressure while increasing cardiac output and renal plasma flow in patients with refractory hypertension.

Cite This Study

Andersson et al. (1985) studied this question.

synapsesocial.com/papers/6a8a537aaf6b08ee8d722c62 https://doi.org/10.1097/00005344-198505000-00021

Topics

Hypertension management

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Implication

Acute felodipine effects in refractory hypertension should not yet change practice; leaves open durability and outcomes in randomized trials.

Systemic and Renal Hemodynamic Effects of Single Oral Doses of Felodipine in Patients with Refractory Hypertension Receiving Chronic Therapy with β-Blockers and Diuretics

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Topics

Systemic and Renal Hemodynamic Effects of Single Oral Doses of Felodipine in Patients with Refractory Hypertension Receiving Chronic Therapy with β-Blockers and Diuretics

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

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