What question did this study set out to answer?

To investigate the acute and long-term effects of felodipine on sympathetic activity, hemodynamics, and the renin-angiotensin-aldosterone system in untreated essential hypertension.

January 12, 1988Acta Medica Scandinavica

Effects of the Calcium Antagonist Felodipine on the Sympathetic and Renin‐Angiotensin‐Aldosterone Systems in Essential Hypertension

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Why the study?

Does felodipine affect sympathetic and renin-angiotensin-aldosterone system activity in patients with essential hypertension?

Population

10 male patients with untreated essential hypertension, WHO grade I-II, aged 25-62 years, hospitalized and…

Design

Cohort

Follow-up

8 weeks

Authors

PKPer KatzmanLund University UHU. Lennart HulthénLund University BHB. HökfeltKarolinska Institutet

Discussion

Member takes

Implication

Supports caution for sympathetic activation with long-term felodipine in hypertension; leaves open effects on cardiovascular outcomes.

Key Points

To investigate the acute and long-term effects of felodipine on sympathetic activity, hemodynamics, and the renin-angiotensin-aldosterone system in untreated essential hypertension.
Studied 10 male patients aged 25-62 years with untreated WHO grade I-II essential hypertension under standardized sodium (150 mmol/day), potassium (75 mmol/day), and water intake.
Evaluated acute responses following a single 10 mg dose and long-term responses after 8 weeks of felodipine (10 mg twice daily) during 8-day and 6-day hospitalizations, respectively.
Acute felodipine significantly reduced blood pressure and increased heart rate, accompanied by significant increases in plasma and urinary noradrenaline, plasma renin activity, and angiotensin II, without changes in adrenaline, dopamine, or aldosterone.
Long-term felodipine produced an equivalent blood pressure reduction without significantly altering heart rate, while plasma noradrenaline (at 3 and 12 hours) and urinary noradrenaline remained increased.
During long-term therapy, plasma renin activity and angiotensin II increased at 3 hours but normalized by 12 hours, while plasma aldosterone was unchanged and urinary aldosterone excretion increased.

Structured PICO

Does felodipine affect sympathetic and renin-angiotensin-aldosterone system activity in patients with essential hypertension?

Population

10 male patients with untreated essential hypertension, WHO grade I-II, aged 25-62 years, hospitalized and maintained on a standardized daily intake of sodium, potassium, and water.

Intervention

Felodipine (acute: 10 mg single dose; long-term: 10 mg twice daily for 8 weeks)

Outcome

Sympathetic activity (plasma and urinary catecholamines), blood pressure, heart rate, and renin-angiotensin-aldosterone system activitysurrogate

Long-term felodipine treatment in essential hypertension lowers blood pressure and induces sustained sympathetic activation without persistent renin-angiotensin system activation.

Cite This Study

Katzman et al. (1988) studied this question.

synapsesocial.com/papers/6a716ff8febe604dd70a1b8c https://doi.org/10.1111/j.0954-6820.1988.tb15776.x

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Effects of the Calcium Antagonist Felodipine on the Sympathetic and Renin‐Angiotensin‐Aldosterone Systems in Essential Hypertension

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Effects of the Calcium Antagonist Felodipine on the Sympathetic and Renin‐Angiotensin‐Aldosterone Systems in Essential Hypertension

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Also Consider

Also Consider