Why the study?
What are the pharmacokinetic properties of intravenous and oral felodipine in healthy men?
Population
8 healthy men, aged 22 to 31 years.
Comparison
Felodipine 27.5 mg oral solution labeled with 25… vs Felodipine 2.5 mg intravenous infusion over 30…
Design
RCT, Randomized, crossover
Follow-up
72 hours
Authors
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Informs felodipine dosing intervals and oral regimens; extends dihydropyridine PK characterization for research.
What are the pharmacokinetic properties of intravenous and oral felodipine in healthy men?
Felodipine exhibits rapid oral absorption but low systemic bioavailability (16%) due to extensive presystemic elimination.
Edgar et al. (1985) studied this question.
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