Why the study?
Can oral peak and trough concentrations of felodipine be accurately predicted from intravenous pharmacokinetic data in patients with congestive heart failure?
Population
11 patients with congestive heart failure
Comparison
Felodipine 10 mg b.i.d. oral therapy for 8 weeks vs Placebo
Design
RCT, randomly allocated, placebo controlled
Follow-up
8 weeks
Authors
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Trough felodipine levels cannot be reliably predicted from IV data in heart failure; challenges stable-pharmacokinetic assumptions for chronic oral dosing.
Can oral peak and trough concentrations of felodipine be accurately predicted from intravenous pharmacokinetic data in patients with congestive heart failure?
Felodipine pharmacokinetics change during chronic oral treatment in heart failure patients, making it impossible to reliably calculate oral dosage schedules from intravenous data.
Dunselman et al. (1989) studied this question.
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