Key result
Felodipine significantly increased exercise duration and improved subjective symptom scores without reflex tachycardia or fluid retention in patients with moderately severe heart failure.
Why the study?
Does felodipine improve exercise duration and hemodynamics in patients with NYHA class III congestive heart failure?
Population
23 patients with congestive heart failure, New York Heart Association class III
Comparison
Felodipine for 8 weeks vs Placebo
Design
RCT, randomized, parallel, double-blind
Follow-up
8 weeks
Authors
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Supports felodipine for functional gains in NYHA III HF; extends vasodilator RCT data to exercise and symptom endpoints.
RCT (n=23)
double-blind
randomized
Does felodipine improve exercise duration and hemodynamics in patients with NYHA class III congestive heart failure?
Felodipine improves exercise duration and symptoms in patients with moderately severe heart failure over an 8-week period.
Dunselman et al. (1989) conducted an RCT in congestive heart failure (n=23). felodipine vs. placebo was evaluated on exercise duration. Felodipine significantly increased exercise duration and improved subjective symptom scores without reflex tachycardia or fluid retention in patients with moderately severe heart failure.
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