Key result
Felodipine adjunctive therapy in severe CHF improved hemodynamics at 6 months, increasing stroke volume by 36% and cardiac output by 30%, alongside enhanced left ventricular ejection fraction.
Why the study?
Does felodipine improve hemodynamic, angiographic, and neurohumoral responses in patients with severe congestive heart failure?
Population
20 patients on conventional therapy for severe congestive heart failure (CHF)
Comparison
Felodipine added to conventional therapy vs Placebo added to conventional therapy
Design
RCT, randomly assigned
Follow-up
6 months
Authors
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Supports adjunctive felodipine for hemodynamic gains in severe CHF; extends short-term data with 6-month RCT findings.
RCT (n=20)
Does felodipine improve hemodynamic, angiographic, and neurohumoral responses in patients with severe congestive heart failure?
In a small cohort of patients with severe heart failure, felodipine improved hemodynamics, left ventricular ejection fraction, and neurohumoral profiles over 6 months.
Kassis et al. (1990) conducted an RCT in severe congestive heart failure (CHF) (n=20). felodipine vs. placebo was evaluated on Clinical, hemodynamic, angiographic, and neurohumoral responses. Felodipine adjunctive therapy in severe CHF improved hemodynamics at 6 months, increasing stroke volume by 36% and cardiac output by 30%, alongside enhanced left ventricular ejection fraction.
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