Key result
Felodipine extended release did not significantly improve exercise test time compared to placebo in patients with mild to moderate heart failure (change of 107 s vs 112 s; P > 0.20).
Why the study?
Does felodipine improve exercise capacity in patients with mild to moderate heart failure?
Population
252 patients aged 18-75 years with NYHA class II or III stable congestive heart failure due to ischaemic…
Comparison
Felodipine extended release formulation 2.5-10… vs Matching placebo 2.5-10 mg twice daily added to…
Design
RCT, randomised in a parallel group study, double blind
Follow-up
12 weeks
Authors
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Does not support felodipine to improve exercise capacity in mild-moderate HF; confirms neutral primary endpoint versus placebo.
RCT (n=252)
Double-blind
parallel group
Yes
Does felodipine improve exercise capacity in patients with mild to moderate heart failure?
Absolute Event Rate: 107% vs 112%
p-value: p=> 0.20
Felodipine does not improve exercise capacity in patients with mild to moderate heart failure and may increase the need for additional heart failure therapies.
Littler et al. (1995) conducted an RCT in mild to moderate heart failure (n=252). felodipine extended release vs. placebo was evaluated on change in exercise test time from baseline to last visit (p=> 0.20). Felodipine extended release did not significantly improve exercise test time compared to placebo in patients with mild to moderate heart failure (change of 107 s vs 112 s; P > 0.20).
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