Key result
Single amlodipine doses yield linear pharmacokinetics and dose-dependent standing DBP reductions up to ~8 mmHg.
Why the study?
What are the pharmacokinetics and comparative bioavailability of three oral doses of amlodipine in healthy male volunteers?
Population
12 healthy male volunteers
Comparison
Single oral dose of 2.5, 5 and 10 mg amlodipine vs Crossover comparison of the three doses
Design
RCT, Randomized, open-label
Follow-up
72 hours
Authors
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Supports once-daily amlodipine titration across this range; confirms linear PK and graded BP effects in healthy volunteers.
RCT (n=12)
Open-label
Randomized
What are the pharmacokinetics and comparative bioavailability of three oral doses of amlodipine in healthy male volunteers?
Amlodipine exhibits linear pharmacokinetics and dose-related blood pressure reductions, supporting its efficacy as a once-daily antihypertensive medication.
Williams et al. (1988) conducted an RCT in Healthy volunteers (n=12). Amlodipine vs. Different doses (crossover) was evaluated on Pharmacokinetics and comparative bioavailability. Single oral doses of 2.5, 5, and 10 mg amlodipine demonstrated linear pharmacokinetics and dose-related reductions in standing diastolic blood pressure (1.1, 4.8, and 8 mmHg at 6 hours).
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