What question did this study set out to answer?

To evaluate the efficacy, safety, and 24-hour blood pressure control of once-daily amlodipine compared with atenolol and placebo in patients with mild-to-moderate essential hypertension.

October 1, 1992American Journal of Hypertension

A Randomized, Placebo-Controlled, Double-Blind Comparison of Amlodipine and Atenolol in Patients With Essential Hypertension

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Why the study?

Does amlodipine or atenolol reduce blood pressure in patients with mild-to-moderate essential hypertension?

Key Points

To evaluate the efficacy, safety, and 24-hour blood pressure control of once-daily amlodipine compared with atenolol and placebo in patients with mild-to-moderate essential hypertension.
Randomized, double-blind, parallel, placebo-controlled trial conducted in 125 patients following a 4-week placebo run-in period.
Participants were allocated to 8 weeks of double-blind treatment with once-daily amlodipine (2.5, 5, or 10 mg; n = 41), atenolol (50 to 100 mg; n = 43), or placebo (n = 41).
Blood pressure was evaluated 24 hours postdose at baseline and final visit, alongside continuous 24-hour profile monitoring and safety assessments.
Amlodipine (mean dose 8.8 mg/day) reduced supine blood pressure by -12.8/-10.1 mm Hg and standing blood pressure by -11.5/-9.8 mm Hg at 24 hours postdose (P < .001 vs baseline).
Atenolol (mean dose 83.7 mg/day) reduced supine blood pressure by -11.3/-11.7 mm Hg and standing blood pressure by -13.3/-12.3 mm Hg (P < .001 vs baseline), with no statistically significant differences between active treatments.
Responder rates were 61.1% for amlodipine, 64.9% for atenolol, and 11.1% for placebo, with heart rate lowered significantly only by atenolol and one amlodipine withdrawal due to peripheral edema, arthralgia, and fatigue.

Structured PICO

Does amlodipine or atenolol reduce blood pressure in patients with mild-to-moderate essential hypertension?

Population

125 patients with mild-to-moderate essential hypertension

Intervention

Amlodipine (2.5 mg, 5 mg, or 10 mg) once daily for 8 weeks

Comparator

Atenolol (50 mg to 100 mg) once daily or placebo for 8 weeks

Outcome

Mean changes from baseline in blood pressure 24 h postdosesurrogate

Amlodipine and atenolol are equally effective and well-tolerated for lowering blood pressure in patients with mild-to-moderate essential hypertension over an 8-week period.

Discussion

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Implication

Either agent may be used initially; confirms short-term equivalence and extends evidence for individualized first-line selection.

Cite This Study

Johnson et al. (1992) studied this question.

synapsesocial.com/papers/6a94ca49222f50f5880b16c3 https://doi.org/10.1093/ajh/5.10.727

Topics

Hypertension management

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A Randomized, Placebo-Controlled, Double-Blind Comparison of Amlodipine and Atenolol in Patients With Essential Hypertension

Key Points

Structured PICO

Discussion

Implication

Cite This Study

Topics

A Randomized, Placebo-Controlled, Double-Blind Comparison of Amlodipine and Atenolol in Patients With Essential Hypertension

Key Points

Structured PICO

Discussion

Implication

Cite This Study

Also Consider

Topics

Also Consider