Why the study?
Does amlodipine reduce blood pressure as effectively as hydrochlorothiazide in patients with mild to moderate hypertension?
Population
145 patients with mild to moderate hypertension
Comparison
Amlodipine 2.5-10 mg once daily, with atenolol… vs Hydrochlorothiazide 25-100 mg once daily, with…
Design
RCT, Randomly allocated, Double-blind
Follow-up
12 weeks (initial monotherapy phase)
Authors
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Amlodipine matches HCTZ for BP control in mild-moderate hypertension; confirms both as effective initial options in this RCT.
Does amlodipine reduce blood pressure as effectively as hydrochlorothiazide in patients with mild to moderate hypertension?
Amlodipine is as effective as hydrochlorothiazide for the treatment of mild-to-moderate hypertension but is associated with a significantly lower incidence of laboratory abnormalities.
Burris et al. (1988) studied this question.
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