Why the study?
Does amlodipine improve blood pressure control compared to hydrochlorothiazide in patients with essential hypertension?
Population
139 patients with essential hypertension
Comparison
Amlodipine 2.5-10.0 mg daily for up to 50 weeks vs Hydrochlorothiazide 25-100 mg daily for up to 50…
Design
RCT, 2:1 patient ratio (amlodipine to HCTZ), Open-label
Follow-up
50 weeks
Authors
Loading...
Supports either as initial monotherapy in essential hypertension; confirms comparable long-term control rates in RCT.
Does amlodipine improve blood pressure control compared to hydrochlorothiazide in patients with essential hypertension?
Amlodipine and hydrochlorothiazide demonstrated comparable efficacy in reducing blood pressure over 50 weeks, though amlodipine was associated with a higher incidence of side effects during the first 12 weeks.
Barry A. Rofman (1988) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: