Key result
The addition of amlodipine to hydrochlorothiazide significantly lowered supine and upright arterial pressures compared to hydrochlorothiazide plus placebo (P<0.001).
Why the study?
Does amlodipine added to hydrochlorothiazide reduce arterial pressure in patients with inadequately controlled hypertension?
Population
40 patients with diastolic arterial pressure supine and upright 95 to 115 mm Hg after 4 weeks of open…
Comparison
Amlodipine added to hydrochlorothiazide 50 mg/d… vs Placebo added to hydrochlorothiazide 50 mg/d for…
Design
RCT, allocated, blindly allocated
Follow-up
12 weeks
Authors
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Supports adding amlodipine to hydrochlorothiazide for uncontrolled hypertension; extends RCT evidence for combination regimens.
RCT (n=40)
Blinded
Does amlodipine added to hydrochlorothiazide reduce arterial pressure in patients with inadequately controlled hypertension?
p-value: p=<0.001
The addition of amlodipine to hydrochlorothiazide safely enhances antihypertensive efficacy and may have favorable effects on lipid profiles.
Chrysant et al. (1989) conducted an RCT in Hypertension (n=40). Amlodipine vs. Placebo was evaluated on Arterial pressure (p=<0.001). The addition of amlodipine to hydrochlorothiazide significantly lowered supine and upright arterial pressures compared to hydrochlorothiazide plus placebo (P<0.001).
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