Why the study?
Does amlodipine added to hydrochlorothiazide reduce blood pressure in patients with essential hypertension inadequately controlled on hydrochlorothiazide alone?
Population
91 hypertensive patients with mild to moderate essential hypertension inadequately controlled on…
Comparison
Amlodipine 2.5 to 10 mg once daily added to… vs Matching placebo added to hydrochlorothiazide
Design
RCT, randomized, parallel group-trial, double-blind
Authors
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Supports adding amlodipine to hydrochlorothiazide for uncontrolled essential hypertension; confirms additive BP reduction in this RCT.
Does amlodipine added to hydrochlorothiazide reduce blood pressure in patients with essential hypertension inadequately controlled on hydrochlorothiazide alone?
Amlodipine is an effective and safe add-on therapy for patients with mild to moderate essential hypertension inadequately controlled on hydrochlorothiazide alone.
Glasser et al. (1989) studied this question.
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