Key result
Once-daily amlodipine significantly reduced blood pressure compared with placebo, with a placebo-corrected mean difference of 16/12 mm Hg supine and 14/4 mm Hg standing at 8 weeks.
Why the study?
Does once-daily amlodipine reduce blood pressure in patients with mild to moderate hypertension?
RCT (n=30)
Double-blind
Does once-daily amlodipine reduce blood pressure in patients with mild to moderate hypertension?
Once-daily amlodipine effectively and safely reduces blood pressure in patients with mild to moderate hypertension.
Answers are grounded in this paper and cite their sources.
Supports once-daily amlodipine for mild-moderate hypertension; confirms and extends prior RCT evidence for dihydropyridine CCBs.
The antihypertensive efficacy of once-daily amlodipine was studied in a group of 30 patients with mild to moderate hypertension in a double-blind, placebo-controlled, parallel-group study. The dose range of amlodipine was 2.5-10.0 mg daily adjusted every 2 weeks for a total treatment period of 8 weeks. Amlodipine produced a significant reduction in blood pressure compared with placebo, the mean difference between baseline and 8 weeks (corrected for placebo effect) being 16/12 mm Hg supine, 14/4 mm Hg standing. Blood pressure returned to baseline values during a terminal 4-week washout period with placebo. There were no significant effects on heart rate. Two patients experienced slight ankle edema while receiving amlodipine 10.0 mg daily but the active drug was otherwise well tolerated.
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Webster et al. (1988) conducted an RCT in Mild to moderate hypertension (n=30). Amlodipine vs. Placebo was evaluated on Reduction in blood pressure from baseline to 8 weeks (MD 16/12 mm Hg supine, 14/4 mm Hg standing). Once-daily amlodipine significantly reduced blood pressure compared with placebo, with a placebo-corrected mean difference of 16/12 mm Hg supine and 14/4 mm Hg standing at 8 weeks.
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