Why the study?
Does once-daily amlodipine reduce 24-hour blood pressure in patients with mild to moderate hypertension?
Population
11 patients with mild to moderate hypertension
Comparison
Amlodipine 5-10 mg once-daily vs Baseline (2-week placebo run-in period)
Design
Cohort, single-blind (during initial 5-mg dose phase)
Follow-up
6 weeks
Authors
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May support once-daily amlodipine for 24-hour BP control in mild-moderate hypertension; hypothesis-generating and requires randomized confirmation.
Does once-daily amlodipine reduce 24-hour blood pressure in patients with mild to moderate hypertension?
Once-daily amlodipine effectively reduces blood pressure throughout a 24-hour period without altering the normal circadian pattern in patients with mild to moderate hypertension.
Raftery et al. (1991) studied this question.
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