Key result
Amlodipine linked to a ~13 mmHg reduction in ambulatory SBP in mild-to-moderate essential hypertension.
Why the study?
Calcium-channel blockers are a mainstay for hypertension with amlodipine preferred for its longer half-life and better safety, prompting evaluation of its 24-hour ambulatory blood pressure control in real-world practice.
Does amlodipine 5/10 mg/day reduce 24-hour ambulatory blood pressure in patients with mild-to-moderate essential hypertension?
Population
104 patients aged 18 to 65 years with mild-to-moderate essential hypertension
Comparison
Amlodipine 5/10 mg/day as monotherapy or add-on therapy
Design
Prospective, multicenter, practice-based observational real-world study
Follow-up
Eight (±1) weeks
Authors
Loading...
May support amlodipine for ambulatory BP lowering in this cohort; hypothesis-generating and leaves open need for randomized confirmation.
Observational (n=104)
Yes
Does amlodipine 5/10 mg/day reduce 24-hour ambulatory blood pressure in patients with mild-to-moderate essential hypertension?
Mean Difference: -13
p-value: p=<0.0001
Amlodipine 5/10 mg/day significantly reduces both office and 24-hour ambulatory blood pressure over 8 weeks in Indian patients with mild-to-moderate essential hypertension.
Prabhakar et al. (2023) conducted an observational in Mild-to-moderate essential hypertension (n=104). Amlodipine vs. Baseline was evaluated on Change from baseline in the mean 24-h SBP and DBP on ambulatory blood pressure monitoring at 8 weeks (MD -13.00, p=<0.0001). Amlodipine 5/10 mg/day significantly reduced mean 24-hour ambulatory systolic blood pressure by 13.00 mmHg and diastolic blood pressure by 9.00 mmHg from baseline over 8 weeks in patients with mild-to-moderate essential hypertension.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: