Why the study?
Does amlodipine administered at bedtime compared to upon awakening improve blood pressure reduction in patients with essential hypertension?
Population
194 patients with grade 1-2 essential hypertension (101 men and 93 women), mean age 55.3±12.1 years.
Comparison
Amlodipine 5 mg/day administered at bedtime for… vs Amlodipine 5 mg/day administered upon awakening…
Design
RCT, randomly assigned
Follow-up
3 months (12 weeks)
Authors
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Timing of amlodipine does not affect 24-hour BP reduction; confirms flexible dosing without chronotherapy benefit in essential hypertension.
Does amlodipine administered at bedtime compared to upon awakening improve blood pressure reduction in patients with essential hypertension?
Amlodipine 5 mg/day provides similar 24-hour blood pressure reduction and does not modify the circadian pattern of BP variability regardless of whether it is administered upon awakening or at bedtime.
Hermida et al. (2005) studied this question.
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