Key result
Evening amlodipine doubles nighttime blood pressure control versus morning dosing without changing office readings.
Why the study?
The comparative antihypertensive efficacy of morning versus evening dosing of amlodipine was unclear.
Does amlodipine administered in the evening improve antihypertensive efficacy compared to morning administration in patients with hypertension?
Population
1215 participants with hypertension from 19 randomized control trials
Comparison
Amlodipine administered in the evening versus morning
Design
Meta-analysis of randomized control trials
Authors
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Evening amlodipine may improve nocturnal BP control; extends chronotherapy evidence for hypertension management.
Meta-Analysis (n=1,215)
Does amlodipine administered in the evening improve antihypertensive efficacy compared to morning administration in patients with hypertension?
Relative Risk: -0.03 (95% CI -0.93–0.88)
p-value: p=0.96
Evening dosing of amlodipine provides superior nighttime blood pressure reduction and improves non-dipper status compared to morning dosing in hypertensive patients.
Luo et al. (2019) conducted a meta-analysis in Hypertension (n=1,215). Amlodipine evening dosing vs. Amlodipine morning dosing was evaluated on Office blood pressure (RR -0.03, 95% CI -0.93-0.88, p=0.96). Evening administration of amlodipine significantly reduced nighttime blood pressure (RR 2.04; 95% CI 1.27-2.81; P<0.00001) compared to morning dosing, though office blood pressure was unaffected.
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