Why the study?
Does morning dosing of amlodipine/valsartan improve 24-h blood pressure compared to evening dosing in hypertensive patients uncontrolled by 5 mg of amlodipine?
Population
463 patients with essential hypertension whose ambulatory blood pressure was uncontrolled after 4 weeks on…
Comparison
Amlodipine/valsartan administered in the morning… vs Amlodipine/valsartan administered in the evening…
Design
RCT, randomized, open-label, blinded endpoint
Follow-up
8 weeks
Authors
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Supports flexible morning or evening dosing of amlodipine/valsartan; confirms chronotherapy equivalence for 24-hour BP control in hypertension.
Does morning dosing of amlodipine/valsartan improve 24-h blood pressure compared to evening dosing in hypertensive patients uncontrolled by 5 mg of amlodipine?
Morning and evening dosing of amlodipine/valsartan provide similar 24-hour blood pressure control in patients with hypertension uncontrolled by amlodipine monotherapy.
Asmar et al. (2011) studied this question.
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