January 1, 1991Journal of Cardiovascular Pharmacology

The Efficacy and Safety of Amlodipine in the Treatment of Mild and Moderate Essential Hypertension in General Practice

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Why the study?

Does amlodipine reduce blood pressure in patients with mild and moderate essential hypertension?

Population

Hypertensive patients with mild and moderate essential hypertension.

Design

Cohort, open

Follow-up

8 weeks

Authors

JVJeanne VarroneGoethe University Frankfurt

Discussion

Member takes

Implication

Supports amlodipine for BP reduction in mild-moderate hypertension; leaves open need for randomized confirmation.

Structured PICO

Does amlodipine reduce blood pressure in patients with mild and moderate essential hypertension?

Population

Hypertensive patients with mild and moderate essential hypertension (sitting diastolic blood pressure 95-115 mm Hg at two consecutive visits).

Intervention

Amlodipine 5 mg once daily, adjusted after 4 weeks to 10 mg once daily to achieve target sitting diastolic blood pressure <= 90 mm Hg, for an 8-week dose adjustment phase.

Outcome

Falls in blood pressuresurrogate

Amlodipine 5-10 mg daily effectively and safely reduces blood pressure in patients with mild to moderate essential hypertension.

Cite This Study

Jeanne Varrone (1991) studied this question.

synapsesocial.com/papers/6a6fb6d95d37378ac1dcc686 https://doi.org/10.1097/00005344-199117001-00011

Topics

Hypertension management

View Full Paper

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The Efficacy and Safety of Amlodipine in the Treatment of Mild and Moderate Essential Hypertension in General Practice

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Topics

The Efficacy and Safety of Amlodipine in the Treatment of Mild and Moderate Essential Hypertension in General Practice

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Topics

Also Consider