What does this research mean for the field?

Amlodipine monotherapy effectively reduces both clinic and ambulatory blood pressure in elderly patients, whereas low-dose hydrochlorothiazide only reduces clinic blood pressure and is inadequate for ambulatory blood pressure control. Novelty: ClaimNovelty.CONTRADICTORY. Consensus alignment: ConsensusAlignment.CHALLENGES_CONSENSUS.

December 1, 1995American Journal of Hypertension

Antihypertensive effects of amlodipine and hydrochlorothiazide in elderly patients with ambulatory hypertension*

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Why the study?

Does amlodipine improve ambulatory blood pressure control compared to hydrochlorothiazide in elderly patients with ambulatory hypertension?

Population

42 elderly patients, mean age 69 years, with confirmed ambulatory hypertension.

Comparison

Amlodipine 5 to 10 mg once daily vs Hydrochlorothiazide 12.5 to 25 mg once daily

Design

RCT, randomized, double-blind

Follow-up

32 weeks

Authors

YLYves LacourcièreGeneral / Preventive / Lipids LPLuc PoirierUniversity of Ottawa JLJean LefèbvreHEC Montréal

Discussion

Member takes

Implication

Amlodipine should be prioritized over low-dose hydrochlorothiazide for 24-hour BP control in elderly hypertensives; challenges thiazide-first recommendations based solely on clinic measurements.

Structured PICO

Does amlodipine improve ambulatory blood pressure control compared to hydrochlorothiazide in elderly patients with ambulatory hypertension?

Population

42 elderly patients (25 men, 17 women), mean age 69 years, with confirmed ambulatory hypertension (clinic sitting diastolic BP 95 to 114 mm Hg and daytime ambulatory diastolic BP >= 90 mm Hg).

Intervention

Amlodipine 5 to 10 mg once daily

Comparator

Hydrochlorothiazide 12.5 to 25 mg once daily

Outcome

Changes in clinic and ambulatory (24-h, daytime, sleep) systolic and diastolic blood pressuressurrogate

Amlodipine monotherapy provides superior 24-hour ambulatory blood pressure control compared to low-dose hydrochlorothiazide in elderly hypertensive patients.

Cite This Study

Lacourcière et al. (1995) studied this question.

synapsesocial.com/papers/6a14a71a6667a4fa718ef5c8 https://doi.org/10.1016/0895-7061(95)00362-2

Topics

Hypertension management

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Implication

Amlodipine should be prioritized over low-dose hydrochlorothiazide for 24-hour BP control in elderly hypertensives; challenges thiazide-first recommendations based solely on clinic measurements.

Antihypertensive effects of amlodipine and hydrochlorothiazide in elderly patients with ambulatory hypertension*

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Topics

Antihypertensive effects of amlodipine and hydrochlorothiazide in elderly patients with ambulatory hypertension*

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Topics

Also Consider