Why the study?
Does amlodipine reduce blood pressure more effectively than verapamil or placebo in patients with mild to moderate essential hypertension?
Population
160 patients with mild to moderate essential hypertension from 16 centers in the United Kingdom and Norway.
Comparison
Amlodipine for 8 weeks. vs Verapamil and placebo.
Design
RCT, double-blind
Follow-up
8 weeks
Authors
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Amlodipine achieves greater BP reduction than verapamil in mild-moderate hypertension; reinforces once-daily dihydropyridine preference with sustained effect.
Does amlodipine reduce blood pressure more effectively than verapamil or placebo in patients with mild to moderate essential hypertension?
Amlodipine once daily is a more effective antihypertensive agent than verapamil twice daily for mild to moderate hypertension, with a sustained 24-hour effect and low incidence of adverse effects.
Lorimer et al. (1988) studied this question.
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