Key result
Amlodipine significantly reduced clinic supine diastolic blood pressure compared to enalapril (95% CI for intergroup difference -17.7 to -2.7; P<0.01) after 8 weeks of treatment.
Why the study?
Does amlodipine improve blood pressure reduction compared to enalapril in patients with moderate/severe hypertension?
Population
31 patients with moderate/severe hypertension (supine DBP 105-125 mm Hg, SBP 140-220 mm Hg)
Comparison
Amlodipine 5-10 mg once daily for 8 weeks vs Enalapril 5-20 mg once daily for 8 weeks
Design
RCT, randomised by the technique of minimisation, observer-blind
Follow-up
8 weeks
Authors
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May support either agent in moderate/severe hypertension; leaves open long-term comparative outcomes.
RCT (n=31)
Observer-blind
minimisation
Does amlodipine improve blood pressure reduction compared to enalapril in patients with moderate/severe hypertension?
p-value: p=<0.01
Amlodipine monotherapy provides a greater reduction in clinic diastolic blood pressure compared to enalapril in patients with moderate to severe hypertension over an 8-week period.
Fowler et al. (1993) conducted an RCT in moderate/severe hypertension (n=31). Amlodipine vs. Enalapril (5-20 mg once daily) was evaluated on Clinic supine diastolic blood pressure (95% CI -17.7, -2.7, p=<0.01). Amlodipine significantly reduced clinic supine diastolic blood pressure compared to enalapril (95% CI for intergroup difference -17.7 to -2.7; P<0.01) after 8 weeks of treatment.
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