Why the study?
Does amlodipine improve blood pressure reduction compared to captopril in adult patients with mild or moderate essential hypertension?
Population
40 adult patients with mild or moderate essential hypertension.
Comparison
Amlodipine 5-10 mg/day oral once-daily vs Captopril 25-50 mg twice daily oral
Design
RCT, double-blind
Authors
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Supports initial use of either agent; confirms comparable efficacy in mild-moderate essential hypertension.
Does amlodipine improve blood pressure reduction compared to captopril in adult patients with mild or moderate essential hypertension?
Amlodipine and captopril provide comparable antihypertensive efficacy and safety for mild to moderate essential hypertension.
Velasco et al. (1991) studied this question.
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