Key result
Azelnidipine and amlodipine produced similar reductions in 24-hour systolic blood pressure (-13 mmHg), but azelnidipine decreased pulse rate by 2 beats/min while amlodipine significantly increased it by 4 beats/min.
Why the study?
Does azelnidipine improve 24-h blood pressure and pulse rate compared to amlodipine in patients with essential hypertension?
RCT (n=45)
Double-blind
randomized
Yes
Does azelnidipine improve 24-h blood pressure and pulse rate compared to amlodipine in patients with essential hypertension?
Absolute Event Rate: -13% vs -13%
p-value: p=0.7766
Azelnidipine and amlodipine provide similar 24-hour blood pressure reduction in essential hypertension, but azelnidipine favorably decreases pulse rate compared to an increase seen with amlodipine.
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Supports preferring azelnidipine to avoid heart rate increases; extends evidence differentiating dihydropyridine chronotropic effects.
Kuramoto et al. (2003) conducted an RCT in essential hypertension (n=45). Azelnidipine vs. Amlodipine 5 mg once daily was evaluated on Change in 24-hour average systolic blood pressure from baseline (95% CI -5.5 to 4.1, p=0.7766). Azelnidipine and amlodipine produced similar reductions in 24-hour systolic blood pressure (-13 mmHg), but azelnidipine decreased pulse rate by 2 beats/min while amlodipine significantly increased it by 4 beats/min.
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