Key result
Active antihypertensive treatment with nitrendipine reduced total strokes by 38% (13.0 vs 20.8 per 1000 patient-years, P=0.01) in older Chinese patients with isolated systolic hypertension.
Why the study?
Does active antihypertensive treatment reduce the incidence of stroke and other cardiovascular complications in older Chinese patients with isolated systolic hypertension?
RCT (n=2,394)
Double-blind
Alternate assignment
Yes
Does active antihypertensive treatment reduce the incidence of stroke and other cardiovascular complications in older Chinese patients with isolated systolic hypertension?
Effect estimate: 38% reduction
Absolute Event Rate: 13% vs 20.8%
p-value: p=0.01
Active antihypertensive treatment with a nitrendipine-based regimen significantly reduces strokes, cardiovascular events, and mortality in older Chinese patients with isolated systolic hypertension.
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Supports nitrendipine-based therapy in older Chinese patients with ISH; extends Western systolic hypertension trial findings to Asian cohorts.
Liu et al. (1998) conducted an RCT in Isolated systolic hypertension (n=2,394). Nitrendipine vs. Placebo was evaluated on Total strokes (38% reduction, p=0.01). Active antihypertensive treatment with nitrendipine reduced total strokes by 38% (13.0 vs 20.8 per 1000 patient-years, P=0.01) in older Chinese patients with isolated systolic hypertension.
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