Why the study?
Does stepped-care antihypertensive drug treatment reduce nonfatal and fatal stroke in older persons with isolated systolic hypertension?
Population
4,736 persons aged 60 years and above with isolated systolic hypertension, mean age 72 years, 57% women, 14%…
Comparison
Stepped-care antihypertensive drug treatment… vs Matching placebo
Design
RCT, randomized, double-blind
Follow-up
average 4.5 years
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Supports stepped-care antihypertensive therapy in older patients with isolated systolic hypertension; confirms stroke prevention in this population.
Does stepped-care antihypertensive drug treatment reduce nonfatal and fatal stroke in older persons with isolated systolic hypertension?
In older patients with isolated systolic hypertension, stepped-care antihypertensive therapy starting with low-dose chlorthalidone significantly reduces the risk of fatal and nonfatal stroke.
A 1991 study studied this question.