Key result
Sevoflurane shows no difference in renal biomarkers or creatinine clearance compared to isoflurane.
Why the study?
The effects of sevoflurane and isoflurane on serum glutathione S-transferase concentrations and creatinine clearance as markers of hepatic and renal function were compared.
RCT (n=50)
randomized
No inter-agent differences in GST/creatinine clearance; leaves open effects in prolonged exposure or renal impairment.
The effects of sevoflurane and isoflurane on serum glutathione S-transferase concentrations and creatinine clearance were compared in 50 ASA I-III patients aged over 18 years undergoing body surface surgery of 1-3 h predicted duration. Patients randomly received sevoflurane (n = 24) or isoflurane (n = 26) in nitrous oxide and oxygen (FIO2 = 0.4) via a nonrebreathing system. Fluids were standardised and patient's lungs ventilated to normocapnia. Expired concentration of anaesthetic agent was adjusted to maintain systolic arterial pressure between 70 and 100% of baseline. Patients received significantly less (p < 0.05) sevoflurane (1.0 MAC-h) than isoflurane (1.5 MAC-h). Using serum glutathione S-transferase concentrations and creatinine clearance as markers of hepatic and renal function respectively, no statistically significant differences were identified between the groups.
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Darling et al. (1997) conducted an RCT in ASA I-III patients undergoing body surface surgery (n=50). Sevoflurane vs. Isoflurane was evaluated on Serum glutathione S-transferase concentrations and creatinine clearance. Sevoflurane resulted in no statistically significant differences in serum glutathione S-transferase concentrations and creatinine clearance compared to isoflurane.
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