Key result
Sevoflurane anesthesia shows no association with postoperative renal function changes in normal to moderate dysfunction.
Why the study?
Does sevoflurane anaesthesia affect renal function in patients with varying degrees of baseline renal function?
Observational (n=34)
Does sevoflurane anaesthesia affect renal function in patients with varying degrees of baseline renal function?
p-value: p=<0.05
Sevoflurane anaesthesia of 3-4 hours duration does not cause significant renal damage in patients with normal or insufficient renal function.
Short-duration sevoflurane appears renal-neutral in moderate dysfunction; hypothesis-generating and requires larger randomized confirmation.
The effects of sevoflurane on renal function were investigated in 34 patients anaesthetized with sevoflurane. Based on preoperative serum creatinine levels, patients were classified into three groups: Group 1 (n = 25) had normal renal function (serum creatinine < 1.0 mg/dl); Group 2 (n = 5) had slight renal dysfunction (1.0 < or = serum creatinine < 1.5 mg/dl); Group 3 (n = 4) had moderate renal dysfunction (serum creatinine > or = 1.5 mg/dl]. Serum creatinine, blood urea nitrogen and urine volume were measured preoperatively, and at Days 0, 1, 2, 7 and 28 after operation. Serum creatinine and blood urea nitrogen showed no significant postoperative differences (P < 0.05) in each group, whereas urine volume showed a significant increase until Day 2, with no further changes thereafter. Our results suggest that sevoflurane anaesthesia causes no significant renal damage in patients with normal and insufficient renal function under normal-duration anaesthesia within 3-4 h.
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Nishimori et al. (1997) conducted an observational in Patients undergoing anaesthesia (n=34). Sevoflurane anaesthesia was evaluated on Postoperative changes in serum creatinine and blood urea nitrogen (p=<0.05). Sevoflurane anaesthesia caused no significant postoperative differences in serum creatinine or blood urea nitrogen (P<0.05) across 34 patients with normal to moderate renal dysfunction.
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