Why the study?
Does sevoflurane compared to enflurane worsen postoperative renal function in elective surgical patients with stable renal insufficiency?
Population
41 elective surgical patients with a stable preoperative serum creatinine concentration >= 1.5 mg/dL
Comparison
Sevoflurane at a fresh gas inflow rate of 4… vs Enflurane at a fresh gas inflow rate of 4 L/min…
Design
RCT, randomly allocated
Follow-up
up to 7 days postoperatively
Authors
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Sevoflurane preserves renal function equivalently to enflurane in stable insufficiency despite higher fluoride; supports its perioperative use and extends RCT safety data.
Does sevoflurane compared to enflurane worsen postoperative renal function in elective surgical patients with stable renal insufficiency?
Sevoflurane anesthesia does not worsen postoperative renal function compared to enflurane in patients with preexisting stable renal insufficiency, despite higher peak serum fluoride concentrations.
Conzen et al. (1995) studied this question.
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