Why the study?
Does prolonged inhalation of sevoflurane anesthesia increase serum and urinary inorganic fluoride concentrations in patients without renal disease?
Population
10 patients without renal disease scheduled for prolonged surgery (lasting 13.4 +/- 0.9 hours)
Design
Cohort
Follow-up
Postoperative period (at least 1 day)
Authors
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Prolonged sevoflurane may exceed nephrotoxic fluoride thresholds; leaves open clinical relevance for renal outcomes in larger cohorts.
Does prolonged inhalation of sevoflurane anesthesia increase serum and urinary inorganic fluoride concentrations in patients without renal disease?
Prolonged sevoflurane anesthesia can lead to serum inorganic fluoride concentrations exceeding the nephrotoxic threshold, though clinical nephrotoxicity was not observed in this small cohort.
Kobayashi et al. (1992) studied this question.
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