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All articles of this category An efficient, two step synthesis of 3-(pyrrolidin-3-yl)indoles 4 is described. Indoles react with maleimides in refluxing acetic acid affording 3-(indol-3-yl)succinimides 6 . Reaction times and yields depend on the substituents on the indole 5 . Direct reduction of the succinimides 6 with LAH affords the desired conformationally restricted tryptamine derivatives 4 . 3-(pyrrolidin-3-yl)indoles - tryptamines - 3-(indol-3-yl)succinimides
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Macor et al. (1997) studied this question.
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