Key result
Captopril and eprosartan lower blood pressure similarly, but captopril selectively reduces blood pressure variability.
Why the study?
The comparative effects of captopril and eprosartan on blood pressure, its variability, and baroreceptor reflex in normal and renovascular hypertensive rats were unclear.
Answers are grounded in this paper and cite their sources.
The aim of this investigation is the comparison of captopril and eprosartane influence on the level blood pressure, its variability and baroreceptor reflex in normal rats and rats with vasorenal hypertension. It was shown that hypertensive rats had higher level of blood pressure, heart rate and its variability than normotensive rats. There was no relationship between arterial blood pressure and its variability in normal as well as hypertensive rats. Captopril decreased blood pressure and had no effect on variability of blood pressure. In rats with renovascular hypertension an increased baroreflex and decreased variability of heart rate was note. Eprosartan, as well as captopril, decreased blood pressure, but increased variability of blood pressure in rats with hypertension.
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Рубанова et al. (2007) studied Renovascular hypertension (n=40). Captopril and Eprosartan vs. Baseline / Normotensive controls was evaluated on Mean arterial blood pressure and blood pressure variability (p=<0.05). In rats with renovascular hypertension, both captopril and eprosartan significantly decreased blood pressure, but captopril decreased blood pressure variability whereas eprosartan increased it.
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