Hypoglaucines A−D, Unusual Isoquinoline Dimers from the Roots of Cyclea hypoglauca

This is the authors' abstract. We don't add key points for this paper.

Hypoglaucines A−D (1−4), four unusual isoquinoline dimers, were isolated from the roots of Cyclea hypoglauca. Compound 1 features p-tolylmethanol and 4-(hydroxymethyl)phenol linkages that join two isoquinoline monomers into a 19-membered macrocyclic ring. Compounds 2−4 are bisbenzylisoquinoline derivatives containing a benzoyl unit. The structures of 1−4, including their absolute configurations, were determined by spectroscopic, computational, and single-crystal X-ray diffraction methods. Compound 1 potently inhibited the proliferation of NCI-H1975 cells with an IC50 of 1.43 ± 0.15 μM by inducing G0/G1 phase arrest.