Key result
Tocilizumab prompts ~93% drop in drain output, resolving refractory pericardial effusion.
Why the study?
The clinical implications of elevated IL-6 levels in pericardial fluid during tocilizumab treatment for rheumatoid pericarditis are not well understood.
Population
A 60-year-old woman with rheumatoid arthritis complicated by pericarditis
Comparison
Tocilizumab treatment effect on pericarditis and IL-6 levels
Design
Case report
Authors
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May resolve refractory pericardial effusion in rheumatoid arthritis; hypothesis-generating for IL-6 inhibition in larger cohorts.
Case Report (n=1)
Ozaki et al. (2010) conducted a case report in Systemic sclerosis with refractory pericardial effusion (n=1). Tocilizumab was evaluated on Pericardial effusion size and drain output. Tocilizumab administration resulted in a rapid decline in pericardial drain output from 270 to 20 mL/day and near-complete resolution of refractory pericardial effusion.
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