Key result
Antihypertensive drug classes show no meaningful differences in renal function changes versus thiazides in older adults.
Why the study?
The effects of antihypertensive therapy on renal function have been inadequately investigated in clinical trials involving older adults.
Observational (n=1,296)
Mean Difference: 0.07
p-value: p=<0.05
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Caution advised when selecting antihypertensive classes for renal preservation in older adults; leaves open differential effects on creatinine.
Nicholas L. Smith (1997) conducted an observational in Hypertension (n=1,296). Various antihypertensive medications vs. Thiazide (HCT) users was evaluated on 3-year changes in serum creatinine (MD +0.07 mg/dL, p=<0.05). Various classes of antihypertensive agents showed no major differences in 3-year serum creatinine changes compared to thiazides in older adults without prior renal disease.
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