Key result
Accessory pathway pre-excitation features short PR intervals, slurred wide QRS complexes, and secondary T-wave changes.
Why the study?
The syndrome of auriculoventricular accessory pathway was recognized as a clinical syndrome with characteristic electrocardiographic features, but its detailed description and understanding were limited.
Early accessory pathway syndrome report; leaves open its diagnostic relevance and arrhythmia mechanisms for modern validation.
Article1 November 1944SYNDROME OF AURICULOVENTRICULAR ACCESSORY PATHWAYGEORGE KAPLAN, THEODORE D. COHNGEORGE KAPLANSearch for more papers by this author, THEODORE D. COHNSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-21-5-824 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe first record of this abnormality was described by Wilson1 in 1915, who believed it to be vagal effect. Wedd2 reported another such case in 1921 and called it "A-V nodal rhythm." Hamburger3 in 1924 reported four cases of "intraventricular conduction disturbances with unusual clinical features."Wolff, Parkinson and White4 were the first to recognize this abnormality as a clinical syndrome. The possibility of an accessory pathway producing this picture was first suggested by Holzmann and Scherf.5Electrocardiographic tracings have the following characteristic pattern:a. Short PR interval.b. Prolonged QRS complex with slurring.c. Usually oppositely directed T waves....Bibliography1. WILSON FN: A case in which the vagus influenced the form of the ventricular complex of the electrocardiogram, Arch. Int. Med., 1915, xvi, 1008. CrossrefGoogle Scholar2. WEDD AM: Paroxysmal tachycardia with reference to nomotopic tachycardia and the role of the extrinsic cardiac nerve, Arch. Int. Med., 1921, xxvii, 571. CrossrefGoogle Scholar3. HAMBURGER WW: Bundle branch block. Four cases of intraventricular block showing some interesting and unusual clinical features, Med. Clin. North Am., 1924, xiii, 343. Google Scholar4. WOLFFPARKINSONWHITE LJPD: Bundle branch block with short PR interval in healthy young people prone to paroxysmal tachycardia, Am. Heart Jr., 1930, v, 685. CrossrefGoogle Scholar5. HOLZMANNSCHERF MD: Ueber Elektrokardiogramme mit verkürzter Vorhofkammerdistanz und positiven P-Zacken, Ztschr. f. klin. Med., 1932, cxxi, 404. Google Scholar6. KENT AF: Some problems in cardiac physiology, Brit. Med. Jr., 1914, ii, 105. CrossrefGoogle Scholar7. WOLFERTHWOOD CCFC: The mechanism of production of short PR intervals and prolonged QRS complexes in patients with presumably undamaged hearts: hypothesis of an accessory pathway of auriculo-ventricular conduction (Bundle of Kent), Am. Heart Jr., 1933, viii, 297. CrossrefGoogle Scholar8. WOLFERTHWOOD CCFC: Further observation on the mechanism of the production of a short PR interval in association with prolongation of the QRS complex, Am. Heart Jr., 1941, xxii, 450. CrossrefGoogle Scholar9. BUTTERWORTHPOINDEXTER JSCA: Short PR interval associated with a prolonged QRS complex. A clinical experimental study, Arch. Int. Med., 1942, lxix, 437. CrossrefGoogle Scholar10. WOODWOLFERTHGECKELER FCCCGP: Histologic demonstration of accessory muscular connections between auricle and ventricle in a case of short PR interval and prolonged QRS complex, Am. Heart Jr., 1943, xxv, 454. CrossrefGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: GEORGE KAPLAN; THEODORE D. COHN*Received for publication December 14, 1943.From The Medical Service, Station Hospital, Camp Stoneman, California. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byElectrocardiographic findings in 67,375 asymptomatic subjectsDisturbances of impulse formation and conduction in the pre-excitation (WPW) syndrome—Their bearing on its mechanismNotes on the similarity of QRS complex configurations in the Wolff-Parkinson-White syndrome 1 November 1944Volume 21, Issue 5 Page: 824-829 Keywords Cyclic adenosine monophosphate Electrocardiography Medical services ePublished: 1 December 2008 Issue Published: 1 November 1944 PDF downloadLoading ...
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Kaplan et al. (1944) conducted a review in Syndrome of auriculoventricular accessory pathway (Wolff-Parkinson-White syndrome). Auriculoventricular accessory pathway was evaluated. The syndrome of auriculoventricular accessory pathway is characterized by a short PR interval, prolonged QRS complex with slurring, and usually oppositely directed T waves.
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