Why the study?
Hyperglycemia is common during myocardial infarction and after cardiac surgery and has a detrimental effect on outcomes, but the optimal glycemic target remains uncertain.
Cohort (n=1,395)
No
Odds Ratio: 3.418 (95% CI 1.713–6.821)
p-value: p=<0.001
Hyperglycemia is a frequent observation during acute illness such as myocardial infarction and after major surgery. The proportion of patients with hyperglycemia may be as high as 95% to 100% after cardiac surgery. This stress-induced hyperglycemia has a detrimental effect on outcome after myocardial infarction and cardiac surgery. Mortality may increase by a factor of 4, especially in non-diabetic patients. Control of hyperglycemia to normalize blood glucose is associated with a clear clinical benefit. This effect is most beneficial in nondiabetic patients with hyperglycemia. The exact target level of glycemia is still a matter of investigation, but normalization to values between 80 and 125 mg/dL is probably optimal.
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M. Hiesmayr (2006) conducted a cohort in Rheumatic heart disease (n=1,395). Postoperative blood glucose > 13.0 mmol/L vs. Postoperative blood glucose ≤ 13.0 mmol/L was evaluated on In-hospital all-cause mortality except for suicide (adjusted OR 3.418, 95% CI 1.713-6.821, p=<0.001).
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