PURPOSE: To report a series of cases with asymmetric keratoconus attributed to eye rubbing, discuss its pathogenesis, and review the literature. METHODS: Case reports and literature review. RESULTS: A careful history obtained from 5 patients with asymmetric keratoconus revealed habitual eye rubbing of the more severely affected eye. CONCLUSIONS: Trauma, such as occurs with habitual eye rubbing, plays a role in the pathogenesis of keratoconus.
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Jafri et al. (2004) studied this question.
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