Aging entails oxidative, metabolic, and physiological decline, necessitating safe dietary interventions to promote healthy aging. Lueyang black-bone chicken soup (CS), a complex food matrix rich in bioactive compounds, was characterized and evaluated in a D-galactose (D-gal)-induced aging mouse model. Untargeted metabolomics identified 1,577 metabolites; in silico ADMET screening highlighted creatine, L‑glutamic acid, and anserine as candidate bioactive compounds from CS. Compared with the Gal group, mice receiving CS exhibited mitigated body‑weight loss and elevated activities of superoxide dismutase (SOD), glutathione peroxidase (GSH‑Px) and total antioxidant capacity (T‑AOC) in serum and liver tissue, and alleviated hepatic histopathological alterations. Hepatic RNA-seq revealed that differentially expressed genes were enriched in pathways associated with nonalcoholic fatty liver disease, oxidative phosphorylation, and immune responses. These findings suggest CS may improve antioxidant status and modulate hepatic metabolic‑immune transcriptional responses, supporting its further evaluation as a functional dietary intervention for healthy aging.
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Jian et al. (2026) studied this question.
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