Key result
Pre-hospital atorvastatin linked to ~55% lower in-hospital mortality vs simvastatin in sepsis.
Why the study?
The effect of pre-hospital statin use on in-hospital mortality in septic patients, and differences between atorvastatin and simvastatin, was unclear.
Cohort (n=1,661)
No
Odds Ratio: 0.455
Absolute Event Rate: 18.5% vs 30%
p-value: p=0.032
No takes yet. Share an insight, caveat, or question.
Should not yet change statin selection in sepsis; leaves open whether pre-hospital atorvastatin reduces mortality versus simvastatin.
Ouellette et al. (2015) conducted a cohort in Sepsis (n=1,661). Atorvastatin vs. Simvastatin was evaluated on In-hospital mortality (OR 0.455, p=0.032). Pre-hospital atorvastatin use was associated with significantly lower in-hospital mortality compared to pre-hospital simvastatin use in patients with sepsis (18.5% vs 30.0%, p=0.032).
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